This addresses a question I've had about individual variations in CA 125 levels in women with/without ovarian cancer. It's another refinement in the detection of OC.
Each participant would have their CA125 levels tested annually over the course of 14 years.
With the help of a computer algorithm, the researchers calculated their risk of ovarian cancer according to the woman's age, their original CA125 levels and how those levels had changed over time. The risk of ovarian cancer was then estimated by comparing the serial pattern with known cases of cancer and controls.